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Publications

Squire, J.M., Sjostrom, M. and Luther, P.K. (1976). "Fine-structure of the A-band in cryo-sections. II. Evidence for a length -determining protein in the thick filaments of vertebrate skeletal muscle". In: Proc. Sixth Eur. Cong. Electron Microsc., Jerusalem. Conference proceedings.

Luther, P.K. and Squire, J.M. (1978) "Three-dimensional structure of the vertebrate muscle M-region" J.Mol.Biol. 125, 313-324.

Luther, P.K. and Squire, J.M. (1980) "Three-dimensional structure of the vertebrate muscle A-band. II. The myosin filament superlattice" J.Mol.Biol. 141, 409-439.

Freundlich, A., Luther, P.K. and Squire, J.M. (1980) "High-voltage electron microscopy of crossbridge interactions in striated muscle". J. Muscle Res. Cell Motility, 1, 321-343.

Luther, P.K., Munro, P.M.G. and Squire, J.M. (1981) "Three-dimensional structure of the vertebrate muscle A-band. III. M-region structure and myosin filament symmetry" J.Mol.Biol. 151, 703-730.

Holt, D.B., Lesniak, P. and Luther, P. (1983) "Image processing of SEM micrographs of integrated circuits for defect location." J. Mat. Sci. Letters, 2, 565-569.

Luther, P.K., Holt, D.B. & Lesniak, M. (1983) "Defect analysis of integrated circuits". Inst. Phys. Conf. Ser. No. 68: Chapter 7 (Conference proceedings).

Luther, P.K. & Crowther, R.A. (1984) "Three-dimensional reconstruction from tilted sections of fish muscle M-band" Nature 307, 566-568.

Crowther, R.A. and Luther, P.K. (1984) "Three-dimensional reconstruction from a single oblique section of fish muscle M-band" Nature 307, 569-570.

Squire, J.M., Luther, P.K. and Agnew, G.D. (1986) "Averaging of periodic images using a microcomputer" J.Microsc. 142, 289-300.

Luther, P.K., Lawrence, M. and Crowther, R.A. (1988) "A method for monitoring the collapse of plastic sections in the electron microscope" Ultramicroscopy 24, 7-18. (Cover picture)

Luther, P.K. (1988) "Three-dimensional reconstruction of the Z-line in fish muscle", Eur. J. Cell Biology, 48 , supp 25, 153-156.

Luther, P.K., Michel, C.C., Ryan, U.S. and Squire, J.M. (1989) "Investigation of the surfaces of cultured endothelial cells for regular arrays of molecules using diffraction analysis of electron micrographs" J.Physiology 413, 2P (Abstract).

Crowther, R.A., Luther, P.K. and Taylor, K.A. (1990) "Computation of a three dimensional image of a periodic specimen from a single view of an oblique section" Electron Microscopy Rev. 3, 29-42.

Luther, P.K. "Three-dimensional reconstruction of a simple Z-band in fish muscle" (1991) J. Cell Biol. 113, 1043-1055. (Cover picture)

Sjostrom, M., Squire, M.J., Luther, P., Morris E. and Edman, A-C. (1991) "Cryoultramicrotomy of muscle: improved preservation and resolution of muscle ultrastructure using negatively stained ultrathin cryosections" J. Microscopy 163, 29-42.

Harford, J., Luther, P. & Squire, J. (1994) "Equatorial A-band and I-band X-ray diffraction from relaxed and active fish muscle: further details of myosin crossbridge behaviour". J. Mol. Biol. 239,500-512.

Pask, H.T., Jones, K.L., Luther, P.K. & Squire, J.M. (1994) "M-band structure, M-bridge interactions and contraction speed in vertebrate cardiac muscles". J. Muscle Res. Cell Motility, 15, 633-645.

Luther, P.K. Munro, P.M.G. & Squire, J.M. (1995) "Muscle ultrastructure in the teleost fish". Micron, 26, 431-459.

Luther, P.K. "Symmetry of vertebrate muscle basketweave Z-band", (1995) J. Structural Biology, 115, 275-282.

Serpell, L.C., Sunde, M., Fraser, P.E., Luther, P.K., Morris, E., & Blake, C.C.F. (1995) "The examination of the structure of the transthyretin amyloid fibril by image reconstruction from electron micrographs" J. Molec. Biol. 254, 113-118.

Luther, P.K., Squire, J.M. & Forey, P.L. (1996) "Evolution of the simple lattice and superlattice A-band in vertebrate skeletal muscle", Journal of Morphology 229, 329-335.

Luther, P.K. (1998) Three-dimensional structure of the A-band and localisation of MyBP-C in cardiac muscle. Biophysical Journal, 74:A352. (abstract).

Squire, J., Cantino, M., Chew, M., Denny, R., Harford, J., Hudson, L. & Luther, P. (1998) "Myosin rod-packing schemes in vertebrate muscle thick filaments", J. Structural Biology, 122,128-138.

Harford J., Cantino M., Chew M., Denny R., Hudson L., Luther P., Mendelson R., Morris E. & Squire J. (1998) Myosin crossbridge configurations in equilibrium states of vertebrate skeletal muscle. Heads swing axially or turn upside-down between resting and rigor. Advances in Experimental Medicine & Biology. 453:297-308.

Knupp. C, Luther, P.K., Morris, E.P., Knight, D.P. & Squire, J.M. (1999) Partially systematic molecular packing in the hexagonal columnar phase of dogfish egg case collagen. J. Struct. Biol 126:121-130.

Luther, P.K., Barry, J., Morris, E. & Squire, J.M. (1999) General model for 3D structure of wide and narrow Z-bands in striated muscle. J. Biosciences, 24:143 (abstract).

Knupp C., Munro P.M.G., Luther PK., Ezra E., & Squire JM (2000) Structure of abnormal molecular assemblies (collagen VI) associated with human full thickness macular holes. J. Struct. Biol., 129:38-47.

Luther, P.K. (2000) Three-dimensional structure of a vertebrate muscle Z-band: Implications for titin and a -actinin binding. J. Struct. Biol., 129:1-16.

Cantino, M.E., Brown, L.D., Chew, M., Luther, P.K. & Squire, J.M. (2000) A-band architecture in vertebrate skeletal muscle: polarity of the myosin head array. J. Muscle Research & Cell Motility, 21:681-690.

Luther, P.K., Barry, J. & Squire, J.M. (2002) Three-dimensional structure of a vertebrate wide (slow muscle) Z-band: Lessons on Z-band assembly. J. Mol. Biol. 315:9-19. (Journal Cover).

Luther, P.K. & Squire, J.M. (2002) Muscle Z-band ultrastructure: Titin Z-repeats and Z-band periodicities do not match. J. Mol. Biol. 319:1157-1164.

Cantino, M. E., Chew, M. W., Luther, P. K., Morris, E. & Squire, J. M. (2002) Structure and nucleotide-dependent changes of thick filaments in relaxed and rigor plaice fin muscle. J. Struct. Biol. 137:164-175.

C.Knupp, P.K. Luther & J.M. Squire (2002) Titin organisation and the 3D architecture of the vertebrate striated muscle I-band. J. Mol. Biol. 322:731-739. (Journal Cover).

Luther, P.K.  & Morris, E.P. (2003)  Cryo-electron microscopy of refrozen cryosections.   J. Struct. Biol. 142:233-240. 

J.M. Squire, P.K. Luther & C. Knupp (2003)  Structural evidence for the interaction of C-protein (MyBP-C) with  actin and sequence identification of a possible actin-binding domain. J. Mol. Biol. 331:713-724.

P.K. Luther, R. Padron, S. Ritter, R. Craig and J.M. Squire  (2003) Heterogeneity of Z-band structure within a single muscle sarcomere.   J. Mol. Biol. 332:161-169. (Journal Cover)

Joya, J.E., Kee, A.J., Nair-Shalliker, V., Ghoddusi, M., Nguyen, M-A.T., Luther, P. & Hardeman, E.C.  (2004)  Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofiber repair mechanism.  Human Mol. Gen. 13:2633-2645.

Squire, J.M., Al-Khayat, H.A., Knupp, C., Luther, P.K.  (2005)  Molecular architecture in muscle contractile assemblies.  Adv Protein Chem, 71:17-87.

Burgoyne T, Muhamad F, Luther PK. (2008) Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography. Cardiovasc Res. 77:707-712.

Bödvarsson, B., S. Klim, M. Mørkebjerg, S. Mortensen, C.H. Yoon, J. Chen, J.R. Maclaren, P.K. Luther, J.M. Squire, P.J. Bones, and R.P. Millane. (2008) A morphological image processing method for locating myosin filaments in muscle electron micrographs. Image and Vision Computing. 26:1073-1080.

Luther, P.K., P.M. Bennett, C. Knupp, R. Craig, R. Padron, S.P. Harris, J. Patel, and R.L. Moss. (2008) Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle. J Mol Biol. 384:60-72..

Yoon, C.H., B. Bodvarsson, S. Klim, M. Morkebjerg, S. Mortensen, J. Chen, J.R. Maclaren, P.K. Luther, J.M. Squire, P.J. Bones, and R.P. Millane. (2009) Determination of myosin filament orientations in electron micrographs of muscle cross sections. IEEE Trans Image Process. 18:831-9.

Luther, P.K. (2009)  The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling. J Muscle Res Cell Motil. 115:275-282.

 

 

                Book Chapters and Reviews

Seymour, J. and Luther, P.K. (1987) "Three-dimensional image processing methods for electron micrographs" In "Fibrous Protein Structure and Function (eds. Squire, J.M. and Vibert, P.J.) Academic Press, London.

Squire, J.M., Luther, P.K. and Trinick, J. (1987) "Muscle myofibril architecture" In "Fibrous Protein Structure and Function" (eds. Squire, J.M. and Vibert, P.J.) Academic Press, London.

Squire, J.M., Morris, E.P. & Luther, P.K. (1990) Organisation and Properties of the striated Muscle Sarcomere. In "Molecular Mechanisms in Muscular Contraction" ed. J. Squire 1-48. "Topics in Molecular and Structural Biology" (series editors Neidle & Fuller) Macmillan.

Luther, P.K. (1992) "Section shrinkage and radiation damage" in "Electron Tomography" (ed. J. Frank) Plenum, New York, 39-60.

Harford, J., Cantino, M., Chew, M., Denny, R., Hudson, L., Luther, P., Mendelson, R., Morris, E. & Squire, J. (1998) Myosin crossbridge configurations in equilibrium states of vertebrate skeletal muscle. In "Mechanisms of work production and work absorption in muscle", eds Sugi & Pollack. Plenum Press.

Luther, P.K. (2001) Section shrinkage: Impact for routine and 3D electron microscopy, Microscopy and Analysis, 7-9.

Luther, P.K. (2004) Evolution of the Muscle Lattice in the Vertebrate Kingdom, Microscopy and Analysis, March

Luther, P.K. (2007)   Structural analysis of cardiac muscle by modern electron microscopy.  British Society for Cardiovascular Research Bulletin, 20:4-10.

Luther, P.K. (2007)   Sample shrinkage and radiation damage of plastic sections, in “Electron Tomography, Second Edition” (ed. J. Frank) Springer, New York, 17-48.

Squire, J.M., C. Knupp, and P.K. Luther. 2008. Zebrafish--topical, transparent, and tractable for ultrastructural studies. J Gen Physiol. 131:439-43.